Catalog# / Size：AC67568/500ug

Clone：D209

Isotype：Humanized IgG2

Endotoxin：Less than 0.01 EU per μg determined by LAL gel clotting assay. 

Purity：>95% as determined by SDS-PAGE.

Antibody Type：Monoclonal

Expressed Host：Expi293 Cells

Application：T-cell activation

Reactivity：Human

Concentration：1.0 mg/mL

Form：Liquid

Antibody Type：Monoclonal

Formulation：Supplied as 0.2 μm filtered solution in PBS, pH7.4.

Storage instructions：Shipped at 4°C. Stored at 4°C for 12 months.

Other Names：Anti-4-1BB Antibody; Anti-ILA Antibody

CD137, also known as 4-1BB, is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the TNF receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds with high affinity to the transmembrane 4-1BB Ligand expressed on antigen-presenting cells and myeloid progenitor cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 

1、Nam KO, et al. (2005) The therapeutic potential of 4-1BB (CD137) in cancer. Curr Cancer Drug Targets. 5(5): 357-63.

2、Melero I, et al. (2008) Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies. Trends Pharmacol Sci. 29(8): 383-90.